The Biopathio Delivery Platform
Three engineering layers, each solving a distinct barrier in CNS gene therapy delivery. From ionizable lipid formulation to receptor-targeted BBB transcytosis to CRISPR cargo compatibility.
Schedule a DiscussionThree Layers. One Delivery System.
Each layer addresses a specific barrier that has blocked CNS gene therapy programs from advancing beyond in vitro validation.
LNP Technology
Ionizable lipid composition, formulation parameters, and quality characterization. pKa-optimized for CNS endosomal escape, not hepatic delivery.
View detailsBBB Crossing Mechanism
Surface engineering for receptor-mediated transcytosis across cerebrovascular endothelium. TfR and LRP1 targeting pathways with in vitro validation data.
View detailsCRISPR Payload Compatibility
Dual-cargo formulation for CRISPR-Cas9 RNP, base editors, and prime editors. Encapsulation efficiency and in vitro editing benchmarks in CNS cell models.
View detailsReady to evaluate Biopathio's platform for your program?
We offer formulation feasibility discussions and custom LNP engineering for defined CRISPR payloads.